Understanding how platelets and macrophages help heal abdominal aortic aneurysms
Official title: Defining Novel Roles of Platelets and Macrophages in the Healing of Abdominal Aortic Aneurysm
Funded at University of Cincinnati · NIH-10869063 · Data updated 2026-11-12
This study is looking at how certain blood cells help heal abdominal aortic aneurysms, which can be dangerous for older adults, and aims to find new ways to improve healing and possibly avoid surgery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $445,500 |
| NIH project number | 1R21AG086865-01 |
| Project ID | NIH-10869063 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are at risk for or have been diagnosed with abdominal aortic aneurysms.
✕Less likely to help
Patients who are younger than 65 or do not have abdominal aortic aneurysms may not benefit from this research.
What this research studies
This research investigates the roles of platelets and macrophages in the healing process of abdominal aortic aneurysms (AAA), a serious condition that can lead to sudden death in older adults. The team will explore how these blood components interact and contribute to tissue regeneration at the site of the aneurysm. By using animal models, they aim to uncover the mechanisms behind these interactions and develop new therapeutic strategies that could improve healing and reduce the need for surgery.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance healing in patients with abdominal aortic aneurysms, potentially reducing the need for surgical interventions.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown promise in understanding the roles of platelets in vascular diseases, indicating potential for success.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Owens Iii, Albert Phillip — University of Cincinnati
- Study coordinator: Owens Iii, Albert Phillip
Related research
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-
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-
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-
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A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
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A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.