Understanding how platelets affect sepsis
The regulation and function of platelet FcARIIA in sepsis
['FUNDING_CAREER'] · UNIVERSITY OF UTAH · NIH-10866373
This study is looking at how platelets and their parent cells help the body fight severe infections like sepsis, with the hope of finding new ways to improve treatment and care for patients dealing with this serious condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-10866373 on ClinicalTrials.gov |
What this research studies
This research investigates the role of platelets and their parent cells, megakaryocytes, in the body's response to sepsis, a severe infection that can lead to organ failure. The principal investigator, Dr. Elizabeth Middleton, aims to uncover the biological mechanisms that drive sepsis and identify new therapeutic targets to improve patient outcomes. By using advanced techniques, including humanized transgenic mouse models, the research will explore how platelets contribute to inflammation and infection. The ultimate goal is to enhance the care and quality of life for patients suffering from sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis or those at high risk of developing sepsis.
Not a fit: Patients with non-infectious conditions or those not experiencing sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve survival rates and quality of life for patients with sepsis.
How similar studies have performed: Previous research has shown promising results in understanding the role of platelets in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MIDDLETON, ELIZABETH ANNE — UNIVERSITY OF UTAH
- Study coordinator: MIDDLETON, ELIZABETH ANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.