Understanding how platelets affect HIV persistence in the brain
Revealing the role of platelets in promoting HIV reservoir seeding and persistence in the CNS-resident myeloid cells
This study is looking at how platelets in the brain might affect hidden HIV reservoirs in people living with HIV, and it aims to find ways to stop these reservoirs from forming, which could help lead to a cure for HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | George Washington University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10843962 on NIH RePORTER |
What this research studies
This research investigates the role of platelets in the central nervous system (CNS) and their impact on HIV reservoirs that can persist despite treatment. By studying SIV-infected rhesus macaques, the researchers aim to understand how disrupting platelet formation during the early stages of infection may prevent the establishment of these viral reservoirs. The goal is to develop new strategies that could limit the ability of HIV to rebound after treatment is stopped. This work is crucial for finding a potential cure for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are undergoing treatment and may be at risk of viral rebound.
Not a fit: Patients who are not living with HIV or those who have already achieved a complete viral suppression without any risk of rebound may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively eliminate HIV reservoirs in the brain, potentially curing the infection.
How similar studies have performed: While the approach of targeting platelet involvement in HIV persistence is innovative, similar studies have shown promise in understanding viral reservoirs in other contexts.
Where this research is happening
Washington, United States
- George Washington University — Washington, United States (Active)
Researchers
- Principal investigator: Maggirwar, Sanjay B. — George Washington University
- Study coordinator: Maggirwar, Sanjay B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.