Understanding how platelet signaling works to improve treatments for blood disorders
Investigation of the Cellular and Molecular Mechanisms of Thrombocyte Integrin Signaling
This study is looking at a special part of your blood cells that helps with clotting, to understand how it works and how it can be improved, which could lead to better treatments for people with bleeding disorders like Glanzmann's thrombasthenia and thrombocytopenia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11081730 on NIH RePORTER |
What this research studies
This research investigates the complex interactions of a specific platelet receptor, αIIbβ3, which plays a crucial role in blood clotting. By examining how this receptor changes shape and interacts with other molecules, the research aims to uncover the underlying mechanisms that can lead to better therapies for conditions like Glanzmann's thrombasthenia and thrombocytopenia. The study will utilize advanced techniques, including single-particle cryo-electron microscopy, to visualize the receptor's structure and how it responds to various drugs. This knowledge could help in developing safer and more effective treatments for patients with bleeding disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Glanzmann's thrombasthenia or thrombocytopenia.
Not a fit: Patients with other types of bleeding disorders not related to αIIbβ3 dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve blood clotting in patients with bleeding disorders.
How similar studies have performed: Previous research has shown promise in targeting platelet receptors for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Wang, Zhao — Baylor College of Medicine
- Study coordinator: Wang, Zhao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.