Understanding how Plasmodium parasites shape their endoplasmic reticulum
ER-shaping proteins of Plasmodium
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10841585
This study is looking at how certain proteins in malaria-causing parasites help them grow and infect people, with the hope that understanding these proteins better could lead to new ways to treat malaria.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10841585 on ClinicalTrials.gov |
What this research studies
This research investigates the endoplasmic reticulum (ER) of Plasmodium parasites, which are responsible for malaria. The study focuses on identifying proteins that shape the ER and how these proteins function at different stages of the parasite's life cycle. By using gene-knockout techniques, researchers will analyze the impact of these proteins on the parasite's ability to grow and infect host cells. The findings aim to uncover critical insights into the biology of malaria parasites, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of malaria infection, particularly those living in endemic regions.
Not a fit: Patients who are not at risk of malaria or those who have already been treated for malaria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel anti-malarial therapies targeting the unique biology of Plasmodium parasites.
How similar studies have performed: While research on Plasmodium biology has been extensive, the specific focus on ER-shaping proteins is a novel approach that has not been widely tested.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BHANOT, PURNIMA — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: BHANOT, PURNIMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.