Understanding how plasma cells contribute to KSHV infection in the tonsils
Official title: Defining the role of plasma cells in the establishment of KSHV infection in human tonsil
Funded at Chapman University · NIH-10909966 · Data updated 2026-11-12
This study is looking at how a virus related to Kaposi sarcoma affects certain immune cells in the tonsils, which could help us understand how the virus spreads and causes related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Chapman University NIH-funded |
| Lab location | 1 site (Orange, United States) |
| Project start | September 20, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $104,855 |
| NIH project number | 5R01CA264913-04 |
| Project ID | NIH-10909966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with compromised immune systems, such as HIV-positive patients or organ transplant recipients.
✕Less likely to help
Patients who are not at risk for KSHV infection or do not have immune system vulnerabilities may not benefit from this research.
What this research studies
This research investigates the role of plasma cells in the early stages of Kaposi sarcoma-associated herpesvirus (KSHV) infection, particularly in the human tonsils. By utilizing human tonsil specimens and an ex vivo infection model, the study aims to uncover how KSHV targets plasma cells and how this may influence the establishment of infection in lymphocytes. The researchers will explore the mechanisms by which KSHV manipulates these immune cells, potentially leading to better understanding of KSHV biology and its implications for diseases like Kaposi sarcoma and B cell lymphoproliferative disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating KSHV-related diseases, particularly in vulnerable populations such as those with HIV.
How similar studies have gone: While KSHV research has been ongoing, this specific investigation into the role of plasma cells in tonsil infection is relatively novel and has not been extensively studied.
Where this research is happening
-
Chapman University
Orange, United States Active
Researchers
- Principal investigator: Totonchy, Jennifer E — Chapman University
- Study coordinator: Totonchy, Jennifer E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.