Understanding how placental signaling affects maternal-fetal diseases
Official title: Mapping inter-cellular trophoblast-decidual signaling to its effects on invasion related maternal-fetal diseases
Funded at University of Connecticut Storrs · NIH-11043061 · Data updated 2026-11-12
This study is looking at how certain cells in the placenta communicate with cells in the uterus to help ensure a healthy pregnancy, and it hopes to find new ways to help moms and babies who might face problems like slow growth or high blood pressure during pregnancy.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project start | March 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $73,036 |
| NIH project number | 3K99HD105973-02S1 |
| Project ID | NIH-11043061 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals experiencing complications related to placental invasion, such as fetal growth restriction or preeclampsia.
✕Less likely to help
Patients without any complications related to placental invasion or those not currently pregnant may not receive benefit from this research.
What this research studies
This research investigates the signaling interactions between trophoblasts and the endometrial stromal fibroblasts, which are crucial for proper placental invasion. By examining these interactions, the study aims to uncover the molecular mechanisms that lead to maternal-fetal diseases, such as fetal growth restriction and preeclampsia. The approach combines computational modeling with experimental validation to create a comprehensive understanding of how these processes work. Patients may benefit from insights that could lead to improved treatments or interventions for conditions related to abnormal placental invasion.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for maternal-fetal diseases, potentially improving outcomes for affected pregnancies.
How similar studies have gone: Previous research has shown promising results in understanding placental biology and its implications for maternal-fetal health, indicating that this approach has potential for success.
Where this research is happening
-
University of Connecticut Storrs
Storrs-Mansfield, United States Active
Researchers
- Principal investigator: Suhail, Yasir — University of Connecticut Storrs
- Study coordinator: Suhail, Yasir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.