Understanding how placental growth factor affects brain health in diffuse white matter disease
Elucidating the role of placental growth factor in diffuse white matter disease
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10841490
This study is looking at how a protein called placental growth factor (PlGF) affects brain health in people with diffuse white matter disease, which can lead to memory problems and dementia, to find new ways to help improve thinking skills as we age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10841490 on ClinicalTrials.gov |
What this research studies
This research investigates the role of placental growth factor (PlGF) in diffuse white matter disease, a condition linked to cognitive decline and dementia. By studying both human data and mouse models, the researchers aim to uncover how PlGF contributes to abnormal blood vessel growth in the brain, which can lead to issues like blood-brain barrier leakage and tissue damage. The study will explore the specific cell types involved, the locations of PlGF expression, and the reasons for its increased levels in this disease. This comprehensive approach could reveal new insights into potential treatments for improving cognitive function in aging individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive impairment or dementia associated with diffuse white matter disease.
Not a fit: Patients with cognitive issues not related to diffuse white matter disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive health in patients with diffuse white matter disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of angiogenic factors in brain diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILCOCK, DONNA M — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: WILCOCK, DONNA M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.