Understanding how placental cells protect against HCMV infection
Defining cell-intrinsic trophoblast defenses to HCMV infection
This study is looking at how special cells in the placenta can protect themselves from a virus called human cytomegalovirus (HCMV), which can be harmful to developing babies, and it aims to find ways to help these cells fight off the virus better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11080189 on NIH RePORTER |
What this research studies
This research investigates how trophoblast cells, which are crucial for placental function, defend against human cytomegalovirus (HCMV) infection. By using trophoblast organoids, a new model that mimics the human placenta, the research aims to uncover the mechanisms that allow these cells to resist HCMV and how the virus affects their normal functions. The study will explore specific factors within trophoblasts that may inhibit viral replication, providing insights into potential therapeutic strategies to protect developing fetuses from HCMV-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals, particularly those at risk of HCMV infection or with a history of congenital infections.
Not a fit: Patients who are not pregnant or those who have no risk factors for HCMV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to prevent or mitigate the harmful effects of HCMV infection during pregnancy.
How similar studies have performed: Other research has shown promise in using organoid models to study viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Hatterschide, Joshua — Duke University
- Study coordinator: Hatterschide, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.