Understanding How Placental Cells Develop
Histone Demethylases and Trophoblast Differentiationt
This research explores how specific proteins help placental cells grow and develop, aiming to prevent serious pregnancy problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-11146572 on NIH RePORTER |
What this research studies
Problems with the placenta can lead to serious pregnancy issues like preeclampsia and poor fetal growth, which can also affect health later in life. These issues often begin very early during the placenta's formation. This project focuses on understanding how certain molecules, such as LSD1, guide the development of important placental cells called trophoblasts. By studying these processes in both mouse models and human cells, we hope to uncover the basic steps that ensure a healthy placenta and prevent early developmental errors.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future clinical applications could benefit pregnant individuals at risk for placental disorders.
Not a fit: Patients not experiencing or at risk for pregnancy-associated disorders related to placental dysfunction would not directly benefit from this specific basic science research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating pregnancy complications like preeclampsia and intrauterine growth restriction.
How similar studies have performed: While LSD1 has been implicated in mouse trophoblast stem cells, its specific role in human trophoblast development and the mature placenta is largely unexplored, making this a novel area of investigation.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Paul, Soumen — University of Kansas Medical Center
- Study coordinator: Paul, Soumen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.