Understanding how PKA signaling affects biology and disease
Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11003782
This study is looking at how a specific protein called PKA works in the body and how changes in this protein might be linked to autism, using special techniques to see how it behaves in brain cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11003782 on ClinicalTrials.gov |
What this research studies
This research investigates the role of cAMP-dependent protein kinase (PKA) in regulating biological functions and how these processes are altered in diseases such as autism spectrum disorder. By utilizing advanced techniques in biochemistry, biophysics, and molecular biology, the research aims to uncover the mechanisms of PKA signaling and its impact on cellular functions. The team employs methods like crystallography and cryo-electron microscopy to visualize the structures of PKA complexes, particularly in neuronal cells, to better understand their localization and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related conditions.
Not a fit: Patients without autism spectrum disorder or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological mechanisms underlying autism spectrum disorder and potentially inform new therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding PKA signaling and its implications in various diseases, indicating that this approach has potential for significant advancements.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAYLOR, SUSAN S. — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: TAYLOR, SUSAN S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder