Understanding how Pim1 affects immune cell metabolism during chronic viral infections
Official title: Pim1 regulates metabolic adaptation of effector CD8 cells during chronic viral infection
Funded at Northwestern University at Chicago · NIH-11059370 · Data updated 2026-11-12
This study is looking at how a protein called Pim1 helps immune cells, specifically CD8 T cells, manage their energy when fighting long-lasting viral infections, with the goal of finding ways to boost their effectiveness and improve treatment for people dealing with these infections.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | November 12, 2024 |
| Project end | October 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $189,713 |
| NIH project number | 1R21AI182804-01A1 |
| Project ID | NIH-11059370 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with chronic viral infections who may benefit from enhanced T cell function.
✕Less likely to help
Patients with acute viral infections or those without significant T cell involvement may not receive benefit from this research.
What this research studies
This research investigates the role of Pim1 in regulating the metabolism of CD8 T cells, which are crucial for fighting chronic viral infections. It focuses on how these immune cells adapt their energy production methods during different phases of infection, particularly when they become exhausted due to continuous viral presence. By analyzing the metabolic pathways and signaling involved, the study aims to identify potential targets for enhancing T cell function and improving treatment outcomes for patients with chronic infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for boosting the immune response in patients suffering from chronic viral infections.
How similar studies have gone: Previous research has shown promising results in understanding T cell metabolism and its implications for chronic infections, indicating that this approach has potential for success.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Cui, Weiguo — Northwestern University at Chicago
- Study coordinator: Cui, Weiguo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.