Understanding how PIEZO channels respond to physical forces in cells
Permeation and Gating Mechanisms of Mechanosensitive PIEZO channels
['FUNDING_R01'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11098965
This study is looking at how special channels in our cells respond to physical pressure and help turn that pressure into electrical signals, which is important for things like feeling touch and pain, and keeping our heart healthy, so we can better understand diseases related to these processes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11098965 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which PIEZO channels, which are sensitive to mechanical forces, function in human cells. It aims to uncover how these channels convert physical stress into electrical signals, which is crucial for various bodily functions such as touch, pain sensation, and cardiovascular regulation. By using advanced biochemical and biophysical techniques, the study will explore how changes in pressure and membrane tension affect the activity of PIEZO1 channels. This knowledge could lead to new insights into diseases linked to mechanotransduction, including cardiovascular and neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cardiovascular diseases, neurological disorders, or conditions linked to PIEZO channel dysfunction.
Not a fit: Patients with conditions unrelated to mechanotransduction or PIEZO channel dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating conditions related to abnormal mechanotransduction.
How similar studies have performed: Previous research has shown promise in understanding mechanosensitive channels, but the specific mechanisms of PIEZO channels remain largely untested.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SYEDA, RUHMA — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: SYEDA, RUHMA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiovascular Diseases