Understanding how PI3K Beta affects breast cancer spread
PI3K Beta regulation of tumor metastasis
This study is looking at how a specific protein called PI3K Beta helps breast cancer spread by examining how cancer cells talk to other cells in the body, and it hopes to find new ways to stop this spread, which could lead to better treatments for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10907453 on NIH RePORTER |
What this research studies
This research investigates the role of PI3K Beta in the metastasis of breast cancer, focusing on how tumor and stromal cells, like macrophages and platelets, communicate to promote cancer spread. The study aims to understand the mechanisms by which these cells enhance tumor cell invasion and survival in distant organs. By using selective inhibitors of PI3K Beta, the research will explore how blocking this pathway can reduce tumor cell movement and growth in the body. Patients may benefit from insights that could lead to new treatment strategies targeting metastasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those at risk of metastasis.
Not a fit: Patients with non-breast cancer types or those whose cancer has already metastasized extensively may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer by targeting the mechanisms that allow cancer to spread.
How similar studies have performed: Other research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Bresnick, Anne R — Albert Einstein College of Medicine
- Study coordinator: Bresnick, Anne R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.