Understanding how physical forces shape organ development in zebrafish
Four-dimensional prediction and quantification of how physical forces impact organogenesis in zebrafish
This study is looking at how the forces in our bodies help shape organs as embryos grow, using zebrafish to learn more about how cells change and work together, which could help prevent birth defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Syracuse University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10915427 on NIH RePORTER |
What this research studies
This research investigates the role of mechanical forces in the development of organs during embryonic growth, specifically using zebrafish as a model organism. It aims to uncover how cells change shape and how these changes contribute to the formation of organs, which is crucial for preventing birth defects. By combining cell biology with advanced modeling techniques, the researchers hope to predict how different mechanical forces influence cell behavior and organ structure. This approach could lead to a better understanding of the physical mechanisms that govern organogenesis.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include families with a history of birth defects or those interested in the biological mechanisms of organ development.
Not a fit: Patients with fully developed organs and no history of birth defects may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to new strategies for preventing structural birth defects.
How similar studies have performed: While the specific approach of combining mechanical analysis with organ development is innovative, similar studies have shown promise in understanding the role of physical forces in biological processes.
Where this research is happening
Syracuse, United States
- Syracuse University — Syracuse, United States (Active)
Researchers
- Principal investigator: Manning, Mary Elizabeth Lisa — Syracuse University
- Study coordinator: Manning, Mary Elizabeth Lisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.