Understanding how physical forces affect cells in bleeding disorders and cancer
Mechanical forces in nanoscale biology: From hemostasis to single-molecule centrifugation
This work explores how physical forces influence cells to better understand conditions like bleeding disorders and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11093423 on NIH RePORTER |
What this research studies
Our bodies are constantly influenced by physical forces, which play a crucial role in how cells behave and how tissues form. This project aims to uncover how these forces change the structure and function of molecules, which can trigger specific cell responses. We are developing new tools and methods, like a miniature microscope that fits into a centrifuge, to make it easier for researchers to study these tiny forces. By making these powerful tools more accessible, we hope to open up new areas of discovery in understanding diseases.
Who could benefit from this research
Good fit: Patients with conditions like bleeding disorders, cancer, or immune system issues may find this basic science research relevant to future treatments.
Not a fit: Patients seeking immediate direct treatment or clinical trial participation will not find direct benefit from this foundational research.
Why it matters
Potential benefit: If successful, this fundamental understanding could lead to new ways to prevent or treat conditions such as bleeding disorders and cancer.
How similar studies have performed: The field of mechanobiology has seen vital insights from technological developments, and this work aims to expand those capabilities and access to powerful tools.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wong, Wesley Philip — Boston Children's Hospital
- Study coordinator: Wong, Wesley Philip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.