Understanding how photoreceptor enzymes are regulated in the eye
Official title: Photoreceptor Phosphodiesterase Regulation
Funded at University of New Hampshire · NIH-10872137 · Data updated 2026-11-12
This study is looking at how certain changes in a gene related to a key enzyme in our eyes can affect our vision, especially for those with inherited retinal diseases, to help find new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Hampshire NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 30, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $374,248 |
| NIH project number | 5R01EY033403-03 |
| Project ID | NIH-10872137 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inherited retinal diseases such as retinitis pigmentosa, congenital stationary night blindness, or cone dystrophy.
✕Less likely to help
Patients with retinal diseases not linked to PDE6 mutations may not benefit from this research.
What this research studies
This research investigates the regulation of photoreceptor phosphodiesterase (PDE6), a key enzyme in the visual signaling pathway that affects how our eyes respond to light. By examining inherited mutations in PDE6 genes linked to various retinal diseases, the study aims to uncover the molecular mechanisms behind these conditions. The researchers will utilize next-generation sequencing to identify mutations and explore how these affect enzyme activity and visual function. This work could lead to a better understanding of retinal diseases and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for retinal diseases that cause blindness.
How similar studies have gone: Previous research has shown promising results in understanding the regulation of similar enzymes in other contexts, suggesting potential for success in this area as well.
Where this research is happening
-
University of New Hampshire
Durham, United States Active
Researchers
- Principal investigator: Cote, Rick H — University of New Hampshire
- Study coordinator: Cote, Rick H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.