Understanding how photoreceptor enzymes are regulated in the eye
Photoreceptor Phosphodiesterase Regulation
['FUNDING_R01'] · UNIVERSITY OF NEW HAMPSHIRE · NIH-10872137
This study is looking at how certain changes in a gene related to a key enzyme in our eyes can affect our vision, especially for those with inherited retinal diseases, to help find new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NEW HAMPSHIRE (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10872137 on ClinicalTrials.gov |
What this research studies
This research investigates the regulation of photoreceptor phosphodiesterase (PDE6), a key enzyme in the visual signaling pathway that affects how our eyes respond to light. By examining inherited mutations in PDE6 genes linked to various retinal diseases, the study aims to uncover the molecular mechanisms behind these conditions. The researchers will utilize next-generation sequencing to identify mutations and explore how these affect enzyme activity and visual function. This work could lead to a better understanding of retinal diseases and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with inherited retinal diseases such as retinitis pigmentosa, congenital stationary night blindness, or cone dystrophy.
Not a fit: Patients with retinal diseases not linked to PDE6 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for retinal diseases that cause blindness.
How similar studies have performed: Previous research has shown promising results in understanding the regulation of similar enzymes in other contexts, suggesting potential for success in this area as well.
Where this research is happening
DURHAM, UNITED STATES
- UNIVERSITY OF NEW HAMPSHIRE — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COTE, RICK H — UNIVERSITY OF NEW HAMPSHIRE
- Study coordinator: COTE, RICK H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.