Understanding how phosphorylation affects sleep cycles and temperature regulation
Official title: Role of Phosphorylation in Determining Circadian Period Length and Temperature Compensation
Funded at Dartmouth College · NIH-11051267 · Data updated 2026-11-12
This study is looking into how our body's natural sleep cycles work and how they can be affected by things like temperature, with the hope of finding new ways to help people who have trouble sleeping.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project start | March 16, 2023 |
| Project end | March 15, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HL165774-03 |
| Project ID | NIH-11051267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing sleep disorders, particularly those related to circadian rhythm disruptions.
✕Less likely to help
Patients with sleep disorders not linked to circadian rhythm issues may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind circadian rhythms, which are the natural cycles that regulate sleep and other physiological processes in our bodies. By focusing on how specific phosphorylation events influence the length of these cycles and their ability to adapt to temperature changes, the study aims to fill critical gaps in our understanding of sleep regulation. The researchers will explore the feedback loops that govern these rhythms and how they may be conserved across different species, including humans. This work could lead to new therapies for sleep disorders by identifying the biological pathways involved.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for sleep disorders, enhancing the quality of life for affected patients.
How similar studies have gone: Previous research has shown success in understanding circadian rhythms and their regulation, suggesting that this approach has a solid foundation.
Where this research is happening
-
Dartmouth College
Hanover, United States Active
Researchers
- Principal investigator: Stevenson, Elizabeth-Lauren — Dartmouth College
- Study coordinator: Stevenson, Elizabeth-Lauren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.