Understanding how phosphorylation affects mitochondrial function
Official title: Delineating phosphorylation-mediated regulation of mitochondrial function
Funded at Washington University · NIH-11090526 · Data updated 2026-11-12
This study is looking at how certain changes in proteins inside our cells' powerhouses, called mitochondria, affect how well they produce energy and stay healthy, which could help us understand problems related to energy production in different diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $388,750 |
| NIH project number | 5R35GM151130-03 |
| Project ID | NIH-11090526 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction or metabolic disorders.
✕Less likely to help
Patients with non-metabolic conditions unrelated to mitochondrial function may not benefit from this research.
What this research studies
This research investigates the role of phosphorylation in regulating mitochondrial function, which is crucial for energy production and overall cellular health. By studying specific proteins within mitochondria, the research aims to uncover how these modifications impact metabolic processes and homeostasis. The approach includes mapping the substrates of kinases and examining where these proteins are phosphorylated within the cell. This work could provide insights into the underlying mechanisms of mitochondrial dysfunction, which is linked to various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with mitochondrial dysfunction.
How similar studies have gone: Other research has shown promising results in understanding mitochondrial function through similar biochemical approaches, indicating potential for success in this area.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Niemi, Natalie — Washington University
- Study coordinator: Niemi, Natalie
Related research
Other NIH-funded projects on the same topics.
-
Using MRI to measure brain oxygen levels as an early sign of small vessel disease in the brain
This study is looking at how measuring oxygen levels in the brain with MRI can help spot early signs of small vessel disease, which is linked to memory problems and dementia, especially Alzheimer's, so if you're at risk due to age or high blood pressure, you might be able to participate in MRI scans to learn more about
-
Advanced Methods & Modeling for Better Patient Care
A funding opportunity focused on developing new modeling methods to improve health care for patients through better data use and analytics.
-
Advanced methods and modeling for health research at Washington University
A health research grant at Washington University funds new modeling methods to support future patient-focused studies.
-
Center for Research in Emerging Infectious Diseases: Epidemiology, Surveillance and Pathogenesis
A NIH program will study and monitor emerging viruses from the Midwest U.S. and three Asian sites to understand how they spread and affect people.
-
How Poverty and the Environment Affect Heart Disease in Haiti and Beyond
This grant studies how poverty-related factors like food insecurity, stress, and pollution contribute to heart disease and aims to follow a large group of adults to better understand and prevent the disease.
-
Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.