Understanding how phosphorylation affects mitochondrial function
Delineating phosphorylation-mediated regulation of mitochondrial function
This study is looking at how certain changes in proteins inside our cells' powerhouses, called mitochondria, affect how well they produce energy and stay healthy, which could help us understand problems related to energy production in different diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11090526 on NIH RePORTER |
What this research studies
This research investigates the role of phosphorylation in regulating mitochondrial function, which is crucial for energy production and overall cellular health. By studying specific proteins within mitochondria, the research aims to uncover how these modifications impact metabolic processes and homeostasis. The approach includes mapping the substrates of kinases and examining where these proteins are phosphorylated within the cell. This work could provide insights into the underlying mechanisms of mitochondrial dysfunction, which is linked to various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction or metabolic disorders.
Not a fit: Patients with non-metabolic conditions unrelated to mitochondrial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with mitochondrial dysfunction.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial function through similar biochemical approaches, indicating potential for success in this area.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Niemi, Natalie — Washington University
- Study coordinator: Niemi, Natalie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.