Understanding how phosphatidylserine affects immune responses in tumors
Official title: Deciphering the immunomodulatory functions of phosphatidylserine in the tumor microenvironment
Funded at Washington University · NIH-11070612 · Data updated 2026-11-12
This study is looking at how a substance called phosphatidylserine on cancer cells can help tumors hide from the immune system, and it's for anyone interested in finding better ways to boost cancer treatment by understanding how to overcome this immune suppression.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | April 1, 2025 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $36,046 |
| NIH project number | 1F30CA298743-01 |
| Project ID | NIH-11070612 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with tumors that exhibit immunosuppressive characteristics due to phosphatidylserine exposure.
✕Less likely to help
Patients with tumors that do not express phosphatidylserine or those whose cancer is not influenced by the tumor microenvironment may not benefit from this research.
What this research studies
This research investigates the role of phosphatidylserine (PS) in the tumor microenvironment, focusing on how its exposure on tumor cells can suppress immune responses. By studying mouse models, the researchers aim to identify the mechanisms behind non-apoptotic PS exposure and its effects on immune cells, particularly tumor-associated macrophages. The goal is to uncover strategies to counteract the immunosuppressive effects of PS, potentially improving cancer treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune system's ability to fight cancer.
How similar studies have gone: Other research has shown promising results in targeting immunosuppressive factors in the tumor microenvironment, suggesting that this approach could be effective.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Ellison, Rochelle Marie — Washington University
- Study coordinator: Ellison, Rochelle Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.