Understanding how phosphatidic acid regulates mitochondrial glutaminase activity
Official title: Defining the role of phosphatidic acid as an allosteric regulator of mitochondrial glutaminase
Funded at Cold Spring Harbor Laboratory · NIH-11009960 · Data updated 2026-11-12
This study is looking at how a substance called phosphatidic acid helps control an important enzyme that changes glutamine into other compounds, which could help us understand its role in health issues like brain diseases and cancer, so patients can learn more about how these processes affect their conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project start | March 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $354,240 |
| NIH project number | 5R01GM149957-03 |
| Project ID | NIH-11009960 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with metabolic disorders related to glutamine metabolism or those affected by neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to glutamine metabolism or those not experiencing metabolic dysregulation may not receive any benefit from this research.
What this research studies
This research investigates the role of phosphatidic acid as an allosteric regulator of mitochondrial glutaminase, an enzyme crucial for converting glutamine into glutamate and ammonium. By exploring the mechanisms that control this enzyme's activity, the research aims to uncover new insights into its regulation in various tissues, including the brain and digestive tract. The study employs biochemical techniques to analyze enzyme activity and its implications for metabolic health and disease. Patients may benefit from a better understanding of how dysregulated glutaminase activity contributes to conditions like neurodegeneration and cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for conditions associated with glutaminase dysregulation, such as cancer and neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in targeting glutaminase for therapeutic purposes, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
-
Cold Spring Harbor Laboratory
Cold Spring Harbor, United States Active
Researchers
- Principal investigator: Lukey, Michael — Cold Spring Harbor Laboratory
- Study coordinator: Lukey, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.