Understanding how phosgene and chlorine gas affect lung proteins and finding ways to treat exposure
Official title: Discovery of phosgene and chlorine gas modes of action and therapeutic targets using chemoproteomic profiling strategies
Funded at Battelle Pacific Northwest Laboratories · NIH-10883970 · Data updated 2026-11-12
This study is looking at how harmful gases like phosgene and chlorine affect proteins in the lungs, which can cause breathing problems, and it aims to find out exactly how these gases change lung proteins so that better treatments can be developed for people who are exposed to them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | August 19, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $494,162 |
| NIH project number | 1R56ES035364-01 |
| Project ID | NIH-10883970 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include military personnel and industrial workers who may be at risk of exposure to these toxic gases.
✕Less likely to help
Patients who have not been exposed to phosgene or chlorine gas are unlikely to benefit from this research.
What this research studies
This research investigates the harmful effects of phosgene and chlorine gas on lung proteins, which can lead to serious respiratory issues. By using advanced chemoproteomic profiling techniques, the study aims to identify specific proteins in the lungs that are modified by these toxic gases. This approach will help uncover the molecular mechanisms behind lung injuries caused by these exposures and pave the way for developing targeted therapies. The research focuses on understanding the timing and nature of protein changes after exposure to these gases.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for individuals exposed to phosgene and chlorine gas.
How similar studies have gone: While the specific approach of using chemoproteomic profiling for these gases is novel, similar methodologies have shown promise in identifying therapeutic targets for other toxic exposures.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Lin, Vivian S — Battelle Pacific Northwest Laboratories
- Study coordinator: Lin, Vivian S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.