Understanding how PHF7 helps heart cells regenerate
Official title: Characterization of PHF7 function in mediating cardiac reprogramming
Funded at Ut Southwestern Medical Center · NIH-10785163 · Data updated 2026-11-12
This study is looking at how a protein called PHF7 can help turn heart cells that aren't working well into healthy heart muscle cells, which could lead to better ways to repair hearts after damage like a heart attack.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $156,600 |
| NIH project number | 1K08HL172012-01 |
| Project ID | NIH-10785163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced cardiac injury or have conditions that affect heart function.
✕Less likely to help
Patients with non-cardiac conditions or those who do not have any history of heart disease may not benefit from this research.
What this research studies
This research investigates the role of a protein called PHF7 in the process of cardiac reprogramming, which aims to convert heart fibroblasts into functional heart muscle cells. The approach involves using advanced techniques to analyze how PHF7 can enhance the regeneration of heart tissue after damage, such as from a heart attack. By identifying effective methods to promote this transformation, the research seeks to improve heart repair strategies and ultimately patient outcomes. The study will involve rigorous training and development for the lead investigator to ensure high-quality scientific inquiry.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve heart regeneration after injury.
How similar studies have gone: Previous research has shown promise in cardiac reprogramming, but the specific role of PHF7 in this process is a novel area of investigation.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Bann, Glynnis Garry — Ut Southwestern Medical Center
- Study coordinator: Bann, Glynnis Garry
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.