Understanding how phase separation affects yeast gene transcription
Dissecting the contributions of phase separation to yeast transcription .
['FUNDING_R01'] · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · NIH-10999321
This study is looking at how certain proteins work together in yeast to help turn genes on and off, which is important for understanding how our bodies develop and how some diseases happen when this process goes wrong.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10999321 on ClinicalTrials.gov |
What this research studies
This research investigates the role of phase separation in the assembly of transcription factors and other proteins necessary for gene transcription in yeast. By using techniques like mutagenesis, the researchers aim to clarify how these interactions contribute to the regulation of gene expression. The study seeks to overcome technical challenges related to the small size of transcriptional assemblies and aims to provide insights into the dynamics of these molecular interactions. This understanding could have implications for developmental biology and diseases linked to transcriptional dysregulation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with genetic disorders linked to transcriptional regulation.
Not a fit: Patients with conditions unrelated to transcriptional processes may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing diseases caused by transcriptional dysregulation.
How similar studies have performed: While the specific approach of investigating phase separation in transcription is relatively novel, similar studies have shown promise in understanding molecular interactions in other biological contexts.
Where this research is happening
MEMPHIS, UNITED STATES
- ST. JUDE CHILDREN'S RESEARCH HOSPITAL — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MITTAG, TANJA — ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Study coordinator: MITTAG, TANJA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.