Understanding how phase separation affects yeast gene transcription
Official title: Dissecting the contributions of phase separation to yeast transcription .
Funded at St. Jude Children's Research Hospital · NIH-10999321 · Data updated 2026-11-12
This study is looking at how certain proteins work together in yeast to help turn genes on and off, which is important for understanding how our bodies develop and how some diseases happen when this process goes wrong.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $515,504 |
| NIH project number | 1R01GM154414-01A1 |
| Project ID | NIH-10999321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals with genetic disorders linked to transcriptional regulation.
✕Less likely to help
Patients with conditions unrelated to transcriptional processes may not receive any benefit from this research.
What this research studies
This research investigates the role of phase separation in the assembly of transcription factors and other proteins necessary for gene transcription in yeast. By using techniques like mutagenesis, the researchers aim to clarify how these interactions contribute to the regulation of gene expression. The study seeks to overcome technical challenges related to the small size of transcriptional assemblies and aims to provide insights into the dynamics of these molecular interactions. This understanding could have implications for developmental biology and diseases linked to transcriptional dysregulation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing diseases caused by transcriptional dysregulation.
How similar studies have gone: While the specific approach of investigating phase separation in transcription is relatively novel, similar studies have shown promise in understanding molecular interactions in other biological contexts.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Mittag, Tanja — St. Jude Children's Research Hospital
- Study coordinator: Mittag, Tanja
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.