Understanding how pH levels affect the development of cranial neural crest cells in zebrafish
Intracellular pH Dynamics in Zebrafish Cranial Neural Crest Development
This study is looking at how changes in the acidity inside cells affect the movement and development of certain cells in zebrafish, which can help us understand how problems in these processes might lead to facial development issues in humans.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10916259 on NIH RePORTER |
What this research studies
This research investigates the role of intracellular pH dynamics in the development of cranial neural crest cells using zebrafish as a model organism. By employing advanced live cell imaging techniques, the study aims to uncover how changes in pH influence cell behaviors such as migration and differentiation during embryonic development. The research focuses on understanding the mechanisms that regulate these processes, which are crucial for the formation of various cell types in the craniofacial region. This could provide insights into developmental disorders related to craniofacial abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with craniofacial abnormalities or those interested in the genetic and developmental aspects of such conditions.
Not a fit: Patients who do not have craniofacial abnormalities or related developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of craniofacial development and potential therapeutic strategies for related disorders.
How similar studies have performed: Other research has shown success in using zebrafish models to study developmental processes, indicating that this approach is promising.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Chou-Freed, Cambria — University of California, San Francisco
- Study coordinator: Chou-Freed, Cambria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.