Understanding how pH affects the formation of tooth enamel
Enamel biomineralization; the role of pH cycling
This study is looking at how the acidity levels in your mouth affect the cells that help build strong teeth, with the goal of finding out how to make your enamel healthier and stronger.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10890165 on NIH RePORTER |
What this research studies
This research investigates the process of enamel biomineralization, which is essential for the development of strong and healthy teeth. It focuses on how the pH levels in the enamel matrix influence the behavior of ameloblasts, the cells responsible for enamel formation. By examining the interactions between pH cycling and ameloblast modulation, the study aims to uncover the mechanisms that lead to proper enamel maturation. This could involve analyzing how changes in pH affect cell morphology and signaling pathways critical for enamel development.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with enamel-related conditions, such as amelogenesis imperfecta, or those experiencing enamel hypomineralization.
Not a fit: Patients with fully developed and healthy enamel may not receive any direct benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for dental conditions related to enamel defects, enhancing oral health and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding enamel formation and the role of pH, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Den Besten, Pamela K — University of California, San Francisco
- Study coordinator: Den Besten, Pamela K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.