Understanding how PFK-1, an important enzyme, is regulated by different molecules
Elucidating the complex allosteric regulation of PFK-1, a broadly evolutionarily conserved glycolytic enzyme
This study is looking at how certain molecules affect a key enzyme called PFK-1 that helps our cells produce energy, which could help us understand how problems with this enzyme are connected to metabolic disorders and cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10903188 on NIH RePORTER |
What this research studies
This research investigates the allosteric regulation of PFK-1, a key enzyme involved in glycolysis, which is crucial for energy production in cells. By examining how various molecules bind to PFK-1 and induce changes in its structure and function, the study aims to uncover the mechanisms behind its regulation. This could help explain how dysregulation of PFK-1 is linked to metabolic disorders and cancer. The research employs advanced biochemical techniques to analyze the interactions and conformational changes of the enzyme in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders or cancers associated with dysregulated PFK-1 activity.
Not a fit: Patients with conditions unrelated to metabolic regulation or those not affected by PFK-1 dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting PFK-1 for the treatment of metabolic disorders and certain cancers.
How similar studies have performed: Previous research has shown promising results in understanding allosteric regulation in other enzymes, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Sundberg, Belen — Columbia University Health Sciences
- Study coordinator: Sundberg, Belen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.