Understanding how PFK-1, an important enzyme, is regulated by different molecules
Official title: Elucidating the complex allosteric regulation of PFK-1, a broadly evolutionarily conserved glycolytic enzyme
Funded at Columbia University Health Sciences · NIH-10903188 · Data updated 2026-11-12
This study is looking at how certain molecules affect a key enzyme called PFK-1 that helps our cells produce energy, which could help us understand how problems with this enzyme are connected to metabolic disorders and cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AI184134-01 |
| Project ID | NIH-10903188 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or cancers associated with dysregulated PFK-1 activity.
✕Less likely to help
Patients with conditions unrelated to metabolic regulation or those not affected by PFK-1 dysregulation may not benefit from this research.
What this research studies
This research investigates the allosteric regulation of PFK-1, a key enzyme involved in glycolysis, which is crucial for energy production in cells. By examining how various molecules bind to PFK-1 and induce changes in its structure and function, the study aims to uncover the mechanisms behind its regulation. This could help explain how dysregulation of PFK-1 is linked to metabolic disorders and cancer. The research employs advanced biochemical techniques to analyze the interactions and conformational changes of the enzyme in detail.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting PFK-1 for the treatment of metabolic disorders and certain cancers.
How similar studies have gone: Previous research has shown promising results in understanding allosteric regulation in other enzymes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Sundberg, Belen — Columbia University Health Sciences
- Study coordinator: Sundberg, Belen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.