Understanding how PEX11 affects the structure and function of peroxisomes
Investigating PEX11 roles in shaping peroxisome architecture and dynamics
This study is looking at how a protein called PEX11 helps shape tiny structures in cells called peroxisomes, which are important for our metabolism, using a plant called Arabidopsis to see what happens when PEX11 doesn't work properly, and the findings could help us understand certain metabolic disorders better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11018520 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called PEX11 in shaping the structure of peroxisomes, which are essential organelles involved in various metabolic processes. The study will utilize a plant model, Arabidopsis, to explore how mutations in PEX11 affect the formation of internal vesicles within peroxisomes and their overall function. By employing advanced techniques like CRISPR and confocal microscopy, researchers aim to clarify the mechanisms by which PEX11 influences peroxisome dynamics and biogenesis. This could lead to a better understanding of metabolic disorders linked to peroxisome dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with metabolic disorders that may involve peroxisome dysfunction.
Not a fit: Patients with conditions unrelated to peroxisome function or those not affected by metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of metabolic diseases and potentially lead to new therapeutic strategies for conditions related to peroxisome dysfunction.
How similar studies have performed: While the specific role of PEX11 in peroxisome architecture is being explored, similar research has shown promising results in understanding organelle dynamics and their implications in metabolic processes.
Where this research is happening
Houston, United States
- Rice University — Houston, United States (Active)
Researchers
- Principal investigator: Tharp, Nathan — Rice University
- Study coordinator: Tharp, Nathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.