Understanding how personalized blood pressure control affects cognition in older adults
Precision blood pressure control, cognition and adverse events in older adults: detecting heterogeneity in treatment effects in randomized trialsusing machine-learning approaches
This study looks at how different ways to manage blood pressure can affect the thinking and memory skills of older adults, especially those at risk for Alzheimer's and similar conditions, to find out who benefits the most from more intense treatment and who might face some downsides.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11057202 on NIH RePORTER |
What this research studies
This research investigates how different blood pressure control strategies impact cognitive health in older adults, particularly those at risk for Alzheimer's disease and related dementias. By analyzing data from multiple trials, the study aims to identify which individuals benefit from intensive blood pressure treatment and which may experience adverse effects. The approach utilizes advanced statistical methods to detect variations in treatment effects based on individual health characteristics. This personalized strategy seeks to optimize blood pressure management for older adults, enhancing their cognitive outcomes and minimizing risks.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults with hypertension, particularly those at risk for Alzheimer's disease or related dementias.
Not a fit: Patients who are younger or do not have hypertension or cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to tailored blood pressure management strategies that improve cognitive health and reduce adverse events in older adults.
How similar studies have performed: Previous research has shown mixed results regarding blood pressure control and cognitive outcomes, indicating that this approach could provide new insights into personalized treatment strategies.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Ma, Yuan — Harvard School of Public Health
- Study coordinator: Ma, Yuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.