Understanding how peroxisomes affect brain health and diseases like Alzheimer's
Neuronal Mechanisms of Metabolic and Genetic Defects of the Peroxisome
This study is looking at tiny parts of our cells called peroxisomes to see how they affect brain health and diseases like Alzheimer's, using fruit flies to help us understand how genetics play a role, with the hope of finding better treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11012846 on NIH RePORTER |
What this research studies
This research investigates the role of peroxisomes, essential cellular structures, in various biochemical processes and their impact on diseases such as Alzheimer's. By utilizing advanced techniques like genomics and metabolomics, the study aims to uncover the molecular mechanisms behind peroxisome-related disorders, particularly focusing on peroxisome biogenesis disorders. The research employs Drosophila as a model organism to explore genetic factors that influence peroxisomal function and their implications for neuronal health. Insights gained could lead to better understanding and potential treatments for neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with peroxisome biogenesis disorders or Alzheimer's disease.
Not a fit: Patients with unrelated neurodegenerative conditions or those without genetic or metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new biomarkers and therapeutic strategies for Alzheimer's disease and related conditions.
How similar studies have performed: Previous research has shown promising results in understanding peroxisomal function and its implications for diseases, indicating that this approach has potential for significant findings.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Wangler, Michael Francis — Baylor College of Medicine
- Study coordinator: Wangler, Michael Francis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.