Understanding how peroxisomal dysfunction contributes to liver disease from alcohol use
Official title: Roles of peroxisomal dysfunction in alcohol-related liver disease
Funded at University of Kansas Medical Center · NIH-11043395 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called peroxisomes might be affected by drinking alcohol and how that could lead to liver problems, with the hope of finding new ways to help people with alcohol-related liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | June 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $520,037 |
| NIH project number | 5R01AA030289-04 |
| Project ID | NIH-11043395 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from alcohol-related liver disease or those with a history of significant alcohol consumption.
✕Less likely to help
Patients who do not consume alcohol or have liver disease unrelated to alcohol may not benefit from this research.
What this research studies
This research investigates the role of peroxisomes, which are cellular organelles involved in metabolic processes, in the development of alcohol-related liver disease (ALD). The study aims to uncover how damage to peroxisomes affects bile acid synthesis and contributes to liver injury caused by alcohol consumption. By using a specialized mouse model, researchers will explore the molecular mechanisms linking peroxisomal dysfunction to bile acid disorders and ALD. This could lead to new insights into potential therapeutic targets for patients suffering from alcohol-related liver conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies for patients with alcohol-related liver disease.
How similar studies have gone: While the specific focus on peroxisomal dysfunction in ALD is relatively novel, previous studies have shown that targeting metabolic pathways can lead to improvements in liver disease outcomes.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Zhong, Wei — University of Kansas Medical Center
- Study coordinator: Zhong, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.