Understanding how peripheral nerve stimulation helps relieve chronic pain
Official title: Mechanisms of Action of Peripheral Nerve Stimulation for the Treatment of Chronic Neuropathic Pain
Funded at Stanford University · NIH-10730521 · Data updated 2026-11-12
This study is looking at how a treatment called peripheral nerve stimulation can help people with ongoing nerve pain in their legs, and it will involve 134 participants who will either get regular care or that care plus the new treatment to see how it affects their pain over a year.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $6,522,833 |
| NIH project number | 1RM1NS128956-01A1 |
| Project ID | NIH-10730521 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic neuropathic pain in their lower extremities who have not found relief through conventional medical management.
✕Less likely to help
Patients with acute pain conditions or those who do not have lower extremity neuropathic pain may not benefit from this research.
What this research studies
This research investigates the mechanisms by which peripheral nerve stimulation (PNS) alleviates chronic neuropathic pain. It involves implanting small electrodes near targeted peripheral nerves to deliver electrical currents, which may alter pain processing in the body. The study will include 134 patients with lower extremity chronic neuropathic pain, who will receive either standard medical management or a combination of standard care and PNS therapy. Participants will undergo regular assessments and sensory testing to evaluate their pain response over a year.
Why it matters
Potential benefit: If successful, this research could lead to a non-addictive treatment option for patients suffering from chronic neuropathic pain.
How similar studies have gone: Previous research has shown promising results with peripheral nerve stimulation for pain management, indicating potential for success in this approach.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Hah, Jennifer — Stanford University
- Study coordinator: Hah, Jennifer
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.