Understanding how perineuronal nets affect epilepsy
Role of Perineuronal Nets in Epilepsy
This study is looking at how special structures around certain brain cells might affect epilepsy, which causes seizures, and aims to find new ways to help improve treatments for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10740864 on NIH RePORTER |
What this research studies
This research investigates the role of perineuronal nets (PNNs) in epilepsy, a condition affecting millions worldwide characterized by recurrent seizures. The study focuses on how these specialized structures surrounding certain neurons may influence their electrical activity and overall function in the brain. By examining the interaction between PNNs and GABAergic interneurons, the research aims to uncover mechanisms that could lead to improved treatments for epilepsy. Patients may benefit from insights gained about the excitatory-inhibitory balance in the brain and potential new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with epilepsy who experience recurrent seizures.
Not a fit: Patients with epilepsy who do not respond to GABAergic treatments or those with other neurological disorders unrelated to epilepsy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that better manage or reduce the frequency of seizures in patients with epilepsy.
How similar studies have performed: Previous research has shown promising results in understanding the role of neuronal structures in epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Sontheimer, Harald W — University of Virginia
- Study coordinator: Sontheimer, Harald W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.