Understanding how perianal fistulas develop in Crohn's disease patients of different ancestries
Defining mechanisms of perianal fistula inception in African and European ancestry Crohn's disease patients
['FUNDING_FELLOWSHIP'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10862792
This study is looking at why people with Crohn's disease, especially those of African and European backgrounds, are more likely to develop perianal fistulas, by examining tissue samples from patients who had surgery, to help find better treatments for everyone.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10862792 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind the formation of perianal fistulas in patients with Crohn's disease, focusing on those of African and European ancestry. By collecting and analyzing tissue samples from patients who have undergone surgery for severe Crohn's disease, the study aims to identify genetic and cellular differences that contribute to the higher incidence of fistulas in African ancestry patients. The approach includes advanced single-cell sequencing techniques to explore gene expression patterns in affected tissues. This research seeks to enhance our understanding of Crohn's disease complications and improve treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are Crohn's disease patients with a history of perianal fistulas, especially those of African or European ancestry.
Not a fit: Patients without Crohn's disease or those who do not have a history of perianal fistulas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for perianal fistulas in Crohn's disease patients, particularly those of African ancestry.
How similar studies have performed: While there has been significant research on Crohn's disease, this specific focus on ancestry-related differences in perianal fistula development is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEVANTOVSKY, RACHEL — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: LEVANTOVSKY, RACHEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.