Understanding how peptide toxins interact with sodium channels in the body
Biophysical analysis of interactions between peptide toxins and human sodium channel voltage-sensor domains
This study is looking at how certain toxins interact with sodium channels in the body, which are important for controlling nerve and heart functions, to find new ways to help treat conditions like heart rhythm problems, epilepsy, and pain.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | College of Staten Island NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10515074 on NIH RePORTER |
What this research studies
This research investigates the interactions between peptide toxins and sodium channel voltage-sensor domains, which are crucial for regulating sodium ion flow in the body. By analyzing how these toxins affect sodium channels, the research aims to uncover new insights into their role in various diseases, including cardiac arrhythmias, epilepsy, and pain management. The approach involves studying the structural and functional properties of these toxins to explore their potential as therapeutic agents. Patients may benefit from the development of new treatments targeting sodium channel-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from conditions like cardiac arrhythmias, epilepsy, severe migraines, or chronic pain.
Not a fit: Patients with conditions unrelated to sodium channel dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for managing pain and treating diseases associated with sodium channel dysfunction.
How similar studies have performed: Previous research has shown promise in using peptide toxins to modulate sodium channels, indicating a potential for success in this area.
Where this research is happening
New York, United States
- College of Staten Island — New York, United States (Active)
Researchers
- Principal investigator: Poget, Sebastien F — College of Staten Island
- Study coordinator: Poget, Sebastien F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.