Understanding how peptide toxins interact with sodium channels in the body
Official title: Biophysical analysis of interactions between peptide toxins and human sodium channel voltage-sensor domains
Funded at College of Staten Island · NIH-10515074 · Data updated 2026-11-12
This study is looking at how certain toxins interact with sodium channels in the body, which are important for controlling nerve and heart functions, to find new ways to help treat conditions like heart rhythm problems, epilepsy, and pain.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | College of Staten Island NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $434,200 |
| NIH project number | 1R15GM141976-01A1 |
| Project ID | NIH-10515074 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from conditions like cardiac arrhythmias, epilepsy, severe migraines, or chronic pain.
✕Less likely to help
Patients with conditions unrelated to sodium channel dysfunction may not receive any benefit from this research.
What this research studies
This research investigates the interactions between peptide toxins and sodium channel voltage-sensor domains, which are crucial for regulating sodium ion flow in the body. By analyzing how these toxins affect sodium channels, the research aims to uncover new insights into their role in various diseases, including cardiac arrhythmias, epilepsy, and pain management. The approach involves studying the structural and functional properties of these toxins to explore their potential as therapeutic agents. Patients may benefit from the development of new treatments targeting sodium channel-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for managing pain and treating diseases associated with sodium channel dysfunction.
How similar studies have gone: Previous research has shown promise in using peptide toxins to modulate sodium channels, indicating a potential for success in this area.
Where this research is happening
-
College of Staten Island
New York, United States Active
Researchers
- Principal investigator: Poget, Sebastien F — College of Staten Island
- Study coordinator: Poget, Sebastien F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.