NIH-funded research R01 grant

Understanding how people with central vision loss stabilize their gaze

Official title: Oculomotor Demands for Target Stabilization without Central Vision

Funded at Smith-Kettlewell Eye Research Institute · NIH-11095960 · Data updated 2026-11-12

This study looks at how people with central vision loss, especially from age-related macular degeneration, move their eyes and keep their gaze steady in daily life, aiming to understand the challenges they face when looking at different objects and moving around, so we can find better ways to help them get around safely.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionSmith-Kettlewell Eye Research Institute
NIH-funded
Lab location1 site (San Francisco, United States)
Project startJune 1, 2024
Project endMarch 31, 2029
Funding year2025
Award (this year)$507,928
NIH project number5R01EY036172-02
Project IDNIH-11095960 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are elderly individuals suffering from central visual field loss due to age-related macular degeneration.

Less likely to help

Patients with intact central vision or those with other unrelated visual impairments may not benefit from this research.

What this research studies

This research investigates how individuals with central visual field loss, particularly from age-related macular degeneration, manage their eye movements and gaze stabilization in everyday situations. It focuses on the challenges faced when shifting gaze between objects and maintaining visual stability while moving. By studying these behaviors in a naturalistic context, the research aims to uncover the difficulties that arise from the loss of central vision and how it affects mobility and navigation. The findings could lead to better strategies for helping those affected navigate their environments safely.

Why it matters

Potential benefit: If successful, this research could improve safety and mobility for patients with central vision loss, reducing the risk of falls and injuries.

How similar studies have gone: Previous research has shown success in understanding visual limitations in static contexts, but this approach to studying oculomotor behaviors in dynamic environments is relatively novel.

Where this research is happening

  • Smith-Kettlewell Eye Research Institute
    San Francisco, United States
    Active

Researchers

  • Principal investigator: Shanidze, Natela M. — Smith-Kettlewell Eye Research Institute
  • Study coordinator: Shanidze, Natela M.

Related research

Other NIH-funded projects on the same topics.

  • How our eyes move together and apart to see in 3-D

    A study at a leading eye research center is exploring how each eye moves on its own and how they work together to guide vision, which could improve understanding and treatment of eye alignment problems like strabismus.

    NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11389329

  • Bilirubin-related vision difficulties in children after neonatal jaundice

    This project studies how newborn jaundice with high bilirubin may impact vision and brain areas involved in seeing later in childhood.

    NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11368333

  • How people with central vision loss aim and keep things in view

    This project looks at how people with central vision loss from conditions like age-related macular degeneration move their eyes and head to find and keep things in view during everyday tasks.

    NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11309171

  • Maximizing Visual Potential for People with Age-Related Macular Degeneration

    This grant investigates how people with age-related macular degeneration adapt their eye movements and attention to use the best remaining vision to perform everyday tasks.

    NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11298071

  • How attention can change eye suppression in amblyopia (lazy eye)

    This project tests whether directing attention to the weaker eye can reduce visual suppression for adults with amblyopia (lazy eye).

    NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11285207

  • How the brain coordinates both eyes

    Looking at whether separate brain areas let each eye move on its own or move together, which could help people with eye alignment problems like strabismus.

    NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11116893

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.