Understanding how people with aphasia generate word meanings

The neurocognitive mechanisms underlying semantic feature generation in persons with aphasia

['FUNDING_FELLOWSHIP'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10998199

This study is looking at how people with aphasia can improve their ability to find and say words by exploring the meanings behind them, using a special method called Semantic Feature Analysis, and it aims to better understand how the brain works during this process to help create better treatments for those with this communication challenge.

Quick facts

Phase['FUNDING_FELLOWSHIP']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded)
Locations1 site (PITTSBURGH, UNITED STATES)
Trial IDNIH-10998199 on ClinicalTrials.gov

What this research studies

This research investigates the cognitive processes involved in generating semantic features for word production in individuals with aphasia, a communication disorder affecting millions. It utilizes Semantic Feature Analysis (SFA), a treatment designed to enhance spoken word production by helping patients articulate related meanings of words. The study aims to explore the brain networks involved in this process using advanced imaging techniques to understand how different semantic models influence word generation. By identifying the underlying mechanisms, the research seeks to improve therapeutic approaches for those affected by aphasia.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with aphasia.

Not a fit: Patients who do not have aphasia or those with severe cognitive impairments unrelated to language may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective treatments for improving communication abilities in individuals with aphasia.

How similar studies have performed: Previous research has shown success with similar approaches in understanding cognitive mechanisms in language disorders, suggesting potential for impactful findings in this study.

Where this research is happening

PITTSBURGH, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.