Understanding how people manage their emotions to improve treatment for depression
Official title: Ambulatory phenotyping with real-time indices of discordant affect regulation: Exploring opportunities for targeted intervention in depression
Funded at University of Southern California · NIH-11089528 · Data updated 2026-11-12
This study is looking at how people with depression manage their feelings and body responses in daily life, so we can find better, personalized ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | July 6, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $664,331 |
| NIH project number | 5R01MH133842-03 |
| Project ID | NIH-11089528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include young adults with a history of recurrent major depressive disorder and healthy individuals for comparison.
✕Less likely to help
Patients with other psychiatric disorders unrelated to affect regulation may not benefit from this research.
What this research studies
This research investigates how individuals with depression regulate their emotions and physiological responses in everyday life. By classifying patients into different phenotypes based on their emotional regulation success, the study aims to identify tailored intervention strategies. Participants will undergo assessments both in their daily environments and in controlled lab settings to validate the underlying neural and physiological mechanisms. This approach seeks to enhance the effectiveness of treatments for depression by focusing on personalized strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for individuals suffering from depression.
How similar studies have gone: Previous research has shown promise in using phenotyping approaches to tailor interventions for depression, indicating potential for success in this novel application.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Stange, Jonathan P — University of Southern California
- Study coordinator: Stange, Jonathan P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.