Understanding how people make choices when they are unsure of the outcomes

Cognitive and reward signals for choices under ambiguity

NIH-funded research University of Pittsburgh at Pittsburgh · NIH-10995335

This study looks at how people make choices when they don't have all the information they need, especially focusing on those with neurological and psychiatric conditions, to understand why some decisions might not go well.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pittsburgh at Pittsburgh NIH-funded
Lab location1 site (Pittsburgh, United States)
Project IDNIH-10995335 on NIH RePORTER

What this research studies

This research investigates how individuals make decisions in situations where they lack complete information, focusing on the differences between risk and ambiguity. It explores how cognitive and reward signals influence decision-making, particularly in individuals with neurological and psychiatric disorders. By examining the brain's response to uncertain choices, the study aims to uncover the underlying mechanisms that lead to poor decision-making. Patients may participate in experiments that assess their decision-making processes under various conditions of uncertainty.

Who could benefit from this research

Good fit: Ideal candidates include individuals with neurological or psychiatric disorders that affect decision-making abilities.

Not a fit: Patients who do not experience decision-making impairments or those with conditions unrelated to cognitive or behavioral decision processes may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for helping patients make better decisions in uncertain situations, potentially enhancing their quality of life.

How similar studies have performed: Previous research has shown promising results in understanding decision-making under risk, but this specific focus on ambiguity is less explored, making it a novel approach.

Where this research is happening

Pittsburgh, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.