Understanding how Pellino-1 affects T-cell function during severe lung infections
Official title: Investigating the redox-sensitive E3 ubiquitin ligase Pellino-1 as a driver of T-cell dysfunction during severe lung infection
Funded at Weill Medical Coll of Cornell Univ · NIH-10997678 · Data updated 2026-11-12
This study is looking at how a protein called Pellino-1 might make it harder for your immune cells, which help fight serious lung infections, to work properly, especially if you have a blood cancer, and it’s testing whether a supplement called N-acetylcysteine can help improve their function.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 12, 2024 |
| Project end | August 11, 2028 |
| Funding year | 2024 |
| Award (this year) | $53,974 |
| NIH project number | 1F30HL175968-01 |
| Project ID | NIH-10997678 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with hematologic cancers who are experiencing severe lung infections.
✕Less likely to help
Patients with non-hematologic cancers or those without severe lung infections may not benefit from this research.
What this research studies
This research investigates the role of Pellino-1, a protein that may hinder the effectiveness of CD8 T cells, which are crucial for fighting severe lung infections, particularly in patients with hematologic cancers. The study focuses on how persistent exposure to infections can lead to T-cell dysfunction and explores the potential of the antioxidant N-acetylcysteine to reverse this effect. By examining the relationship between Pellino-1 and T-cell activity, the research aims to identify new strategies to enhance immune responses in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance T-cell function and reduce the risk of severe lung infections in patients with hematologic cancers.
How similar studies have gone: Previous studies have shown promising results with antioxidants like N-acetylcysteine in improving T-cell function during severe infections, indicating that this approach has potential.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Merlinsky, Tiffany Rebecca — Weill Medical Coll of Cornell Univ
- Study coordinator: Merlinsky, Tiffany Rebecca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.