Understanding how Pellino-1 affects T-cell function during severe lung infections
Investigating the redox-sensitive E3 ubiquitin ligase Pellino-1 as a driver of T-cell dysfunction during severe lung infection
['FUNDING_FELLOWSHIP'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10997678
This study is looking at how a protein called Pellino-1 might make it harder for your immune cells, which help fight serious lung infections, to work properly, especially if you have a blood cancer, and it’s testing whether a supplement called N-acetylcysteine can help improve their function.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10997678 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Pellino-1, a protein that may hinder the effectiveness of CD8 T cells, which are crucial for fighting severe lung infections, particularly in patients with hematologic cancers. The study focuses on how persistent exposure to infections can lead to T-cell dysfunction and explores the potential of the antioxidant N-acetylcysteine to reverse this effect. By examining the relationship between Pellino-1 and T-cell activity, the research aims to identify new strategies to enhance immune responses in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with hematologic cancers who are experiencing severe lung infections.
Not a fit: Patients with non-hematologic cancers or those without severe lung infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance T-cell function and reduce the risk of severe lung infections in patients with hematologic cancers.
How similar studies have performed: Previous studies have shown promising results with antioxidants like N-acetylcysteine in improving T-cell function during severe infections, indicating that this approach has potential.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MERLINSKY, TIFFANY REBECCA — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: MERLINSKY, TIFFANY REBECCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway infections