Understanding how PD1 affects heart inflammation during heart failure
Mechanism of PD1 on cardiac inflammation resolution during heart failure development
This study is looking at how a protein called PD1 affects inflammation in the heart during heart failure, and it's for anyone interested in understanding how our immune system can impact heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-11015906 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called PD1 in managing inflammation in the heart, particularly during heart failure. It aims to uncover how PD1 influences immune responses that can either help or hinder heart health. By studying immune cells from mice with heart failure, researchers will analyze how PD1 affects inflammation and the overall health of the heart. The approach includes advanced techniques like single-cell sequencing to gain insights into the cellular changes that occur during heart failure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or those at risk of developing heart failure.
Not a fit: Patients without heart failure or those with unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage heart inflammation and improve outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown that understanding immune responses in heart conditions can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Chen, Yingjie — University of Mississippi Med Ctr
- Study coordinator: Chen, Yingjie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.