Understanding how PD-L1 and PD-1 interact to improve cancer treatment
Regulation of PD-L1/PD-1 immune checkpoints by cis-interactions
This study is looking at how certain proteins help cancer cells hide from the immune system, with the goal of finding ways to make cancer treatments work better for more people.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11023019 on NIH RePORTER |
What this research studies
This research investigates the PD-L1/PD-1 immune checkpoint pathway, which plays a crucial role in how tumors evade the immune system. By exploring the interactions between PD-L1 on tumor cells and PD-1 on immune cells, the study aims to uncover mechanisms that could enhance the effectiveness of existing cancer immunotherapies. The researchers will focus on how these proteins communicate and influence each other's functions, particularly through a newly discovered interaction with the CD28 receptor. This work could lead to strategies that expand the benefits of PD-1 and PD-L1 blockade therapies to more patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers that are currently treated with PD-1 or PD-L1 blockade therapies.
Not a fit: Patients whose cancers do not involve the PD-L1/PD-1 pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments that are effective for a broader range of patients.
How similar studies have performed: Previous research has shown promising results in targeting the PD-L1/PD-1 pathway, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Hui, Enfu — University of California, San Diego
- Study coordinator: Hui, Enfu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.