Understanding how PD-1 affects immune cells and gut damage in colitis
Unraveling the Role of PD-1 in CD8+ Tissue-Resident Memory T Cell Homeostasis and Epithelial Damage in Human Colitis
['FUNDING_CAREER'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11061076
This study is looking at how a part of the immune system called PD-1 affects certain immune cells in the gut and how this might lead to colitis, a painful side effect some people experience after immunotherapy, with the goal of finding ways to prevent or better manage this condition.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11061076 on ClinicalTrials.gov |
What this research studies
This research investigates the role of PD-1 in the immune response of CD8+ tissue-resident memory T cells and their involvement in causing colitis, a severe side effect of immunotherapy. The study aims to identify the immune mechanisms that lead to epithelial damage in patients who develop colitis after receiving PD-1 blockade treatment. By analyzing human samples and utilizing advanced immunological techniques, the research seeks to uncover the specific immune drivers responsible for this condition. The findings could provide insights into preventing or managing colitis in patients undergoing immunotherapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have developed colitis as a side effect of PD-1 blockade therapy.
Not a fit: Patients who have not received PD-1 blockade therapy or do not have colitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating colitis in patients receiving PD-1 blockade therapy.
How similar studies have performed: Other research has shown success in understanding immune responses in similar contexts, but this specific investigation into PD-1-related colitis is relatively novel.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOMAS, MOLLY — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: THOMAS, MOLLY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.