Understanding how PBRM1 affects lung immune cells
Official title: The Involvement of PBRM1 in Alveolar Macrophage Development, Homeostasis, and Immune Function
Funded at University of California, San Diego · NIH-11018603 · Data updated 2026-11-12
This study is looking at a protein called PBRM1 to see how it helps lung immune cells called alveolar macrophages fight infections and keep your lungs healthy, which could lead to better treatments for people with respiratory diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $41,251 |
| NIH project number | 5F31HL167460-03 |
| Project ID | NIH-11018603 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with respiratory conditions or those at risk of lung infections, particularly older adults.
✕Less likely to help
Patients with non-respiratory conditions or those without any lung health issues may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, PBRM1, in the development and function of alveolar macrophages, which are crucial immune cells in the lungs. By studying how these cells respond to infections and maintain lung health, the research aims to uncover mechanisms that could improve immune responses in patients with respiratory diseases. The approach involves analyzing how PBRM1 influences the behavior of these macrophages through various biological processes, including their ability to clear pathogens and regulate inflammation. This could lead to new insights into treating lung diseases and enhancing immune function.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for respiratory infections and other lung-related diseases by enhancing the immune response.
How similar studies have gone: Previous research has shown promising results in understanding immune cell functions in lung health, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Rattu Mandias, Hannah Caroline — University of California, San Diego
- Study coordinator: Rattu Mandias, Hannah Caroline
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.