Understanding how past malaria infections affect vaccine responses in children
Mechanisms of compromised CD8 T cell responses to vaccination in malaria experienced hosts
This study is looking at how having malaria before affects how well kids in malaria-prone areas respond to vaccines, using a mouse model to help understand this better and find ways to make vaccines work better for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11124154 on NIH RePORTER |
What this research studies
This research investigates how previous malaria infections impact the immune response to vaccines in children living in malaria-endemic regions. By using a mouse model that mimics human malaria infections, the study aims to uncover the mechanisms behind reduced vaccine efficacy in individuals who have experienced malaria. The researchers will analyze immune responses to a specific type of vaccine that has shown promise in preventing malaria, with the goal of improving vaccine strategies for affected populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have experienced malaria infections and live in regions where malaria is common.
Not a fit: Patients who have never been exposed to malaria or who are outside the targeted age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective malaria vaccines for children in endemic areas, ultimately reducing malaria incidence and improving health outcomes.
How similar studies have performed: Previous research has shown that understanding immune responses in malaria-experienced individuals can lead to advancements in vaccine development, indicating potential success for this approach.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Harty, John T — University of Iowa
- Study coordinator: Harty, John T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.