Understanding how past malaria infections affect vaccine responses
Integrating human and non-human primate data to understand the acquisition of pre-erythrocytic immunity in the face of previous malaria exposure
['FUNDING_U01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11087472
This study is looking at how past malaria infections affect how well malaria vaccines work, especially in places where malaria is common, by examining both monkeys and people to learn more about the immune system's response.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11087472 on ClinicalTrials.gov |
What this research studies
This research investigates how previous malaria infections influence the immune response to malaria vaccines, particularly in regions where malaria is common. By studying both non-human primates and human participants, the researchers aim to uncover the mechanisms behind varying vaccine effectiveness. The approach includes detailed analysis of immune responses at the cellular level, focusing on tissue resident memory T cells in the liver, which are crucial for understanding immunity. The findings could help improve malaria vaccine strategies in endemic areas.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in malaria-endemic areas who have had previous malaria infections.
Not a fit: Patients who have never been exposed to malaria or those living in non-endemic regions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective malaria vaccines that provide better protection for individuals in endemic regions.
How similar studies have performed: Previous research has shown that understanding immune responses in animal models can inform vaccine development, suggesting potential for success in this approach.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WILDER, BRANDON KEITH — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: WILDER, BRANDON KEITH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: acute infection