Understanding how PARP inhibitors affect bone marrow health
Official title: Mechanisms of Parp inhibitor-induced bone marrow toxicities
Funded at University of Wisconsin-Madison · NIH-11082346 · Data updated 2026-11-12
This study is looking at how a type of cancer drug called PARP inhibitors affects bone marrow health and blood cell production, to help identify which patients might be more at risk for side effects based on their genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $387,195 |
| NIH project number | 5R01HL168184-03 |
| Project ID | NIH-11082346 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include cancer patients who are being treated with PARP inhibitors and those with specific genetic mutations affecting their bone marrow.
✕Less likely to help
Patients who are not undergoing treatment with PARP inhibitors or do not have blood-related conditions may not benefit from this research.
What this research studies
This research investigates the effects of PARP inhibitors, a class of cancer drugs, on bone marrow function and health. It aims to understand how these drugs, which are effective in treating various cancers, may also cause serious side effects in normal blood cells. By studying the mechanisms behind these adverse effects, the research seeks to identify which patients might be more vulnerable due to genetic factors. The approach involves analyzing blood cell formation and the response of bone marrow cells to these drugs.
Why it matters
Potential benefit: If successful, this research could lead to safer cancer treatments by minimizing harmful side effects associated with PARP inhibitors.
How similar studies have gone: Previous research has shown that understanding drug interactions with bone marrow can lead to improved safety profiles for cancer treatments, indicating potential for success in this area.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Churpek, Jane Ellen — University of Wisconsin-Madison
- Study coordinator: Churpek, Jane Ellen
Related research
Other NIH-funded projects on the same topics.
-
BRAVE Innovation Center for Viral Resistance in Chickens
A center at UW–Madison aims to create chickens genetically resistant to avian viruses like H5N1 by identifying host genes involved in virus replication using genome-wide CRISPR screening.
-
Center to Fight Vector-Borne Diseases in the Midwest
A Midwest program brings researchers, public health teams, and vector-control groups together to prevent diseases spread by ticks and mosquitoes.
-
Globally useful predictor for cervical cancer treatment response
This project aims to develop a simple predictive signature to personalize treatment for locally advanced cervical cancer using easy tests and imaging.
-
Neutrophil development with stem cells to understand their behavior
Researchers are studying how neutrophils, a type of immune cell, develop from stem cells to better understand why they can help or harm in infections and inflammatory diseases.
-
WREN: Expanding Research Capacity in Rural Primary Care Clinics
A nationwide network in Wisconsin will strengthen rural primary care clinics to participate in real-world research and bring more clinical trials to communities.
-
Targeting early oral GVHD to improve mouth health after stem cell transplant
A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.