Understanding how PARP-1 helps repair DNA damage
Tuning PARP-1 retention and release on DNA breaks
This study is looking at how a protein called PARP-1 helps fix DNA damage, which could lead to better treatments for cancer and other related conditions, so patients can learn how to improve their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11042271 on NIH RePORTER |
What this research studies
This research investigates the role of PARP-1, a protein that responds to DNA breaks, in the repair of genetic damage. By examining how PARP-1 binds to and modifies proteins at sites of DNA damage, the study aims to uncover the mechanisms that regulate its activity. This could lead to improved therapies for cancer and other conditions related to DNA damage. Patients may benefit from insights into how to enhance or inhibit PARP-1 activity for better treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancers that are known to involve DNA repair deficiencies.
Not a fit: Patients with conditions unrelated to DNA damage or those not affected by cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer therapies that target DNA repair mechanisms.
How similar studies have performed: Previous research has shown promising results with PARP inhibitors in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Black, Ben E. — University of Pennsylvania
- Study coordinator: Black, Ben E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.