Understanding how parasitic worms eliminate DNA
Programmed DNA Elimination in Parasitic Nematodes
This study is looking at how certain parasites, like Ascaris and Toxocara, get rid of parts of their DNA during their life cycle, which could help us find new ways to treat infections caused by these worms, especially in kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Knoxville NIH-funded |
| Lab location | 1 site (Knoxville, United States) |
| Project ID | NIH-10901875 on NIH RePORTER |
What this research studies
This research investigates a unique process in parasitic nematodes, such as Ascaris and Toxocara, where they eliminate specific DNA segments as part of their life cycle. The study aims to uncover the molecular mechanisms behind this programmed DNA elimination, which is crucial for understanding how these parasites manage their genetic material. By examining how these worms reorganize their chromosomes and the role of DNA double-strand breaks, the research could provide insights into potential treatments for infections caused by these parasites, particularly in children. The approach involves detailed genetic analysis and observation of chromosomal behavior in these organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under the age of 11 who are infected with parasitic nematodes like Ascaris or Toxocara.
Not a fit: Patients who are not infected with these specific parasitic nematodes or who are over the age of 21 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating infections caused by parasitic nematodes, potentially reducing morbidity in affected populations, especially children.
How similar studies have performed: While the specific approach of programmed DNA elimination in these parasitic nematodes is relatively novel, similar genetic studies in other organisms have shown promising results in understanding genome organization and function.
Where this research is happening
Knoxville, United States
- University of Tennessee Knoxville — Knoxville, United States (Active)
Researchers
- Principal investigator: Wang, Jianbin — University of Tennessee Knoxville
- Study coordinator: Wang, Jianbin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.