Understanding how Pannexin channels work in the nervous system
Official title: Elucidating structures and molecular mechanisms of Pannexin channels
Funded at Northwestern University at Chicago · NIH-11215804 · Data updated 2026-11-12
This study is looking at special channels in the nervous system that help send signals and release energy, with the hope of finding new ways to treat conditions like inflammation and nerve protection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 2, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $363,789 |
| NIH project number | 7R35GM138321-06 |
| Project ID | NIH-11215804 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with neurological disorders or conditions related to inflammation.
✕Less likely to help
Patients with conditions unrelated to purinergic signaling or Pannexin channel dysfunction may not benefit from this research.
What this research studies
This research investigates the Pannexin family of channels, which are crucial for purinergic signaling in the nervous system. By exploring how these channels facilitate the release of ATP and their roles in various physiological processes, the research aims to uncover their potential as therapeutic targets for diseases. The study employs biochemical and physiological methods to analyze the structure and function of Pannexin channels, which could lead to new insights into their involvement in conditions like neuroprotection and inflammation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for a variety of neurological and inflammatory conditions by targeting Pannexin channels.
How similar studies have gone: While the specific mechanisms of Pannexin channels are still being explored, there is growing interest in their role in various diseases, indicating potential for success in similar research.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Lu, Wei — Northwestern University at Chicago
- Study coordinator: Lu, Wei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.